Related Experiment Videos
Antidepressants and postoperative complications in breast reduction surgery: A retrospective association study
John Yuxuan Ha1, Victor F A Almeida2, Fernando Ribeiro Duraes1
1Department of Plastic Surgery, Institute of Dermatology and Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Summary
Preoperative antidepressant use in breast reduction surgery is linked to higher risks of infection, wound dehiscence, and sepsis. Opioid prescribing also increased, but bleeding complications were not affected.
Area of Science:
- Plastic Surgery
- Pharmacology
- Surgical Outcomes
Background:
- Antidepressant use impact on surgical outcomes is unclear, especially for breast reduction.
- Potential risks include infection, wound complications, and bleeding, affecting surgical decisions.
Purpose of the Study:
- To investigate the association between preoperative antidepressant use and postoperative complications after breast reduction surgery.
Main Methods:
- Retrospective multicenter cohort study using TriNetX (2010-2025).
- Adults undergoing bilateral breast reduction were analyzed.
- Propensity score matching balanced demographics and comorbidities.
Main Results:
- Antidepressant use (n=7411) was associated with increased infection (5.1% vs 4.1%), wound dehiscence (4.1% vs 2.8%), and sepsis (0.4% vs 0.2%).
- Higher opioid prescribing (29.1% vs 23.8%) was observed in antidepressant users.
- Selective serotonin reuptake inhibitors (SSRIs) showed slightly higher risks than serotonin-norepinephrine reuptake inhibitors (SNRIs).
Conclusions:
- Preoperative antidepressant exposure correlates with modest increases in infection, wound dehiscence, sepsis, and postoperative opioid prescribing.
- Bleeding complications were not significantly increased.
- Findings are observational and require further validation.
Related Concept Videos
01:28Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
01:23Antidepressant Drugs: MAOIs and Other Agents
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
01:25Antidepressant Drugs: Overview
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...