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Site-Specific Lysine Lactylation via Genetic Code Expansion in E. coli and Mammalian Cells
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Lactate as a Chemical Modification on Proteins and Metabolites

Shuke Xiao1,2,3, Andrew L Markhard1,2, Jonathan Z Long4,1,3,2,5

  • 1Department of Pathology, Stanford School of Medicine, Stanford, California, USA;

Annual Review of Biochemistry
|June 22, 2026
PubMed
Abstract

Keywords:
N-lactoyl amino acidscovalentglycolysislactatelactylation

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