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Updated: Jun 24, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Nucleic sexual hormone receptor signaling pathways in breast cancer: function regulation, crosstalk, and therapeutic
Kai Zeng1, Anqi Wang2, Hongmiao Sun1
1Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, Liaoning Province, China.
Abstract:
Sexual hormone receptors (SHRs) are essential for breast cancer (BCa) pathogenesis. BCa is a prevalent malignancy with high heterogeneity and high recurrence. Endocrine resistance remains a major clinical challenge. SHR-mediated transcription involves complex epigenetic, post-translational, and inter-receptor crosstalk, and dysregulation of these processes contributes to endocrine resistance. This review aims to summarize the current progress on the molecular mechanism underlying the function of nucleic SHRs in BCa, providing insights for the novel therapeutic strategies in BCa.
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