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Related Experiment Video

Updated: Jun 24, 2026

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Integrative Transcriptomic and Proteomic Profiling Identifies S100P as a Potential Functional Biomarker for Sessile

Jen-Hao Yeh^1,2,3, Chia-Chi Chen^3,4, Chih-I Chen^3,5

¹Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.

Digestive Diseases and Sciences

|June 22, 2026

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Summary

Sessile serrated lesions (SSLs) are hard to detect but S100P shows promise as a biomarker. Further validation is needed for this colorectal cancer precursor.

Area of Science:

Gastroenterology
Oncology
Molecular Biology

Background:

Sessile serrated lesions (SSLs) contribute to 15% of colorectal cancers (CRCs).
SSLs present diagnostic challenges due to their flat morphology and subtle histological features.

Purpose of the Study:

To discover novel biomarkers for SSLs.
To validate potential biomarkers using transcriptomic and multi-omics approaches.

Main Methods:

RNA sequencing of paired SSL and normal mucosa specimens.
Filtering differentially expressed genes (DEGs) for membrane or secretory proteins.
Validation using TCGA and adenoma transcriptomes, CRISPR dependency, proteotranscriptomic concordance, and pharmacogenomic analysis.

Main Results:

Keywords:

Biomarker Colon polyp Colonoscopy Colorectal cancer Sessile serrated lesion Transcriptomics

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Last Updated: Jun 24, 2026

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Identified 216 upregulated genes in SSLs, with 68 secretory/membrane proteins distinguishing SSLs from controls.
S100P emerged as a key biomarker candidate, consistently upregulated in SSLs and CMS1 tumors.
Demonstrated S100P RNA-protein concordance and identified pharmacogenomic vulnerabilities in serrated colorectal cancer cells.

Conclusions:

S100P is a promising biomarker candidate for sessile serrated lesions.
Further validation in larger cohorts and clinical platforms is recommended.
Identified potential therapeutic targets and pathways for SSLs.