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Recent vaccination exposure and central serous chorioretinopathy
Maria Anna Bantounou1,2, Dimitra Foteinou3, Maria Emfietzoglou1,2
1Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA.
Eye (London, England)
|June 22, 2026
Summary
Recent vaccination may increase central serous chorioretinopathy (CSCR) risk shortly after immunization. While overall vaccination within 90 days showed no link, a 1-10 day window suggests a potential association requiring further study.
Area of Science:
- Ophthalmology
- Immunology
- Epidemiology
Background:
- Central serous chorioretinopathy (CSCR) involves choroidal hyperpermeability and cytokine dysregulation.
- Vaccination activates cytokine pathways, prompting investigation into its association with CSCR.
Purpose of the Study:
- To assess the association between vaccination and incident central serous chorioretinopathy (CSCR).
- To evaluate CSCR risk in relation to vaccination timing and vaccine type.
Main Methods:
- A case-control study was conducted using the Mass General Brigham database (adults 18-60 years).
- CSCR cases were matched 4:1 to controls based on demographics and relevant health factors.
- Vaccination within 90 days pre-index was analyzed overall, by vaccine category, and by specific time windows.
Main Results:
- No overall association between vaccination within 90 days and CSCR (OR 1.14).
- Vaccination within 1-10 days prior to index was linked to increased CSCR odds (OR 2.00, P=0.043).
- Case-crossover analysis confirmed temporal clustering of CSCR post-vaccination (OR 3.25, P=0.039).
Conclusions:
- A short-term association exists between vaccination and CSCR risk (1-10 days post-vaccination).
- No link found for vaccination within 90 days; current vaccination practices for CSCR patients need no change.
- Further research with comprehensive vaccine data is needed to confirm acute post-vaccination CSCR risk.
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