Related Experiment Video
Updated: Jun 24, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
Chronic kidney disease following pediatric cardiac surgery: a systematic review and meta-analysis
Hamidreza Badeli1, Mahsa Motiei1, Azita Tangestani Nejad2
1Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Insights
Chronic kidney disease (CKD) affects 16% of pediatric patients post-cardiac surgery. Long-term renal monitoring is crucial for these children, though more research is needed to confirm prevalence.
Area of Science:
- Pediatric Nephrology
- Cardiology
- Public Health
Background:
- Chronic kidney disease (CKD) is a significant long-term concern for children after cardiac surgery.
- Improved survival rates in pediatric cardiac surgery patients necessitate focus on long-term health outcomes.
- The actual prevalence of CKD in this population is not well-established due to limited data.
Conclusions:
- The study indicates a substantial prevalence of CKD in pediatric cardiac surgery survivors.
- Long-term renal monitoring is recommended for this patient group.
- Further high-quality studies with standardized definitions and extended follow-up are needed.
Background:
Chronic kidney disease (CKD) is a potential long-term complication in children undergoing cardiac surgery. With improved survival rates in this population, attention has shifted toward long-term outcomes, yet the true burden of CKD remains unclear due to limited data.
Objectives:
To determine the pooled prevalence of chronic kidney disease among pediatric patients with a history of cardiac surgery.
Materials And Methods:
A systematic literature search was conducted in PubMed, Scopus, and Web of Science from inception to March 1, 2025. Eligible studies included those reporting CKD prevalence in patients under 18 years of age who had undergone any type of cardiac surgery. We performed this systematic review and meta-analysis following PRISMA guidelines and Cochrane Collaboration recommendations using a random-effects model. Pooled prevalence estimates were calculated with 95% confidence intervals (95% CI).
Results:
Data from five prospective studies involving 1002 pediatric patients were included. The studies were published between 2016 and 2022 and conducted in Canada, France, the United States, and Belgium. The pooled prevalence of CKD was 16% (95% CI: 9.0-26.0%), with moderate heterogeneity across studies (I² = 49.5%, p = 0.09). Sensitivity analysis confirmed the stability of the pooled estimate.
Conclusions:
The findings of this analysis highlight the need for long-term renal monitoring in this population, although further high-quality studies with standardized definitions and extended follow-up are warranted to confirm and refine these estimates.
Related Concept Videos
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease I: Introduction
Chronic Kidney Disease IV: Nursing Management
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury V: Interprofessional Care
Kidney Transplant I: Introduction
