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Published on: January 26, 2024
First-trimester plasma targeted metabolomics for eicosanoids reveals predictive potential and preventive targets for
Yongqiang Ma1, Linjie Li2, Yiwen Fang2
1Department of Cardiology, Characteristic Medical Center of the CPAPF, 220, Chenglin Road, Dongli District, Tianjin, 300162, China.
BMC Pregnancy and Childbirth
|June 23, 2026
Summary
This study identified specific eicosanoid metabolites in first-trimester blood that can predict severe preeclampsia. A novel ratio improved prediction accuracy, offering potential strategies for prevention.
Area of Science:
- Cardiovascular homeostasis
- Metabolomics
- Pregnancy complications
Background:
- Eicosanoids are vital for cardiovascular health.
- Early metabolic profiles of severe preeclampsia are not fully understood.
- This study investigates eicosanoids for predicting severe preeclampsia.
Purpose of the Study:
- Identify eicosanoid metabolites in first-trimester blood.
- Assess their predictive potential for severe preeclampsia.
- Develop novel prediction models.
Main Methods:
- Prospective cohort study of 5,809 pregnant women.
- Nested case-control analysis of 45 severe preeclampsia cases and 41 controls.
- Targeted metabolomic analysis using UPLC-MS/MS.
Main Results:
- Ten eicosanoid metabolites differed significantly between groups.
- Cyclooxygenase (COX) and 12/15-lipoxygenase (LOX) metabolites were upregulated.
- Cytochrome P450 (CYP450) metabolites were downregulated.
- The 14-HDoHE/19,20-EDP ratio significantly improved prediction (AUC 0.77 to 0.87).
Conclusions:
- Novel first-trimester eicosanoid metabolomic models predict severe preeclampsia.
- Findings support aspirin use for COX inhibition.
- Rebalancing 12/15-LOX and CYP450 pathways may prevent severe preeclampsia.
