Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metal-organic framework-derived confined nanomaterials: a unified platform for catalysis, sensing, and energy applications.

Materials horizons·2026
Same author

Effects of rumen-protected glucose supplementation strategies on growth performance, colonic fermentation, and meat quality in Simmental beef cattle.

Animal bioscience·2026
Same author

Genome Mining of Deep-Sea Cold Seep-Derived Fungus Reveals a Laccase-Fasciclin System Modulating Regioselective Naphthopyranone Dimerization.

International journal of molecular sciences·2026
Same author

Surface Gradient Doping Enables High-Capacity and Long-Life Manganese-Based Prussian Blue Cathodes for Sodium-Ion Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Unraveling Water-Defect Coupled Degradation via Deuterium Isotope Labeling in Prussian Blue Analogue Cathodes for Long-Life Sodium-Ion Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Interfacial carbon-regulated charge transfer and ROS evolution in Ag<sub>3</sub>PO<sub>4</sub> for enhanced photo-persulfate activation.

Environmental research·2026

Related Experiment Video

Updated: Jun 24, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
10:49

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

pH-modulating binary hydrogen-bonded organic frameworks accelerate diabetic wound healing.

Junpeng Sun1,2,3,4, Xiang Sun1,5, Mei Xia1,4

  • 1Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong; Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.

Journal of Nanobiotechnology
|June 23, 2026
PubMed
Summary

A novel fabric coated with a binary hydrogen-bonded organic framework (SMU-8@W) effectively treats diabetic foot ulcers. This material modulates wound pH, combats infection, and promotes healing by enhancing angiogenesis and collagen production.

Keywords:
AntibacterialDiabetic foot ulcerHydrogen bond organic frameworksWound infectionpH modulating

Related Experiment Videos

Last Updated: Jun 24, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
10:49

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

Area of Science:

  • Biomaterials Science
  • Wound Healing Research
  • Nanotechnology

Background:

  • Diabetic foot ulcers (DFUs) present a significant clinical challenge due to impaired healing linked to pH dysregulation and infection.
  • Effective management requires strategies that address both the microbial and microenvironmental factors contributing to non-healing wounds.

Purpose of the Study:

  • To develop and evaluate a novel fabric-based therapeutic agent (SMU-8@W) for enhanced diabetic foot ulcer healing.
  • To investigate the capacity of a hydrogen-bonded organic framework (SMU-8) to modulate the wound microenvironment and combat infection.

Main Methods:

  • Fabrication of SMU-8@W by coating a fabric with a binary hydrogen-bonded organic framework (SMU-8).
  • Assessment of SMU-8@W's photodynamic activity for infection suppression.
  • Evaluation of the material's ability to guide pH transitions within the wound microenvironment.
  • Characterization of hemostatic performance, moisture permeability, biosafety, and stability.

Main Results:

  • SMU-8@W demonstrated potent photodynamic activity, effectively suppressing wound infection.
  • The material guided a "near-neutral-weakly acidic-near-neutral" pH transition, optimizing the wound microenvironment.
  • SMU-8@W exhibited excellent hemostatic properties (BCI = 21.19 ± 2.52%), high moisture permeability (5874.20 ± 196.03 g·m⁻²·d⁻¹), biosafety, and stability.
  • The material effectively managed wound exudate and reduced inflammation, accelerating healing.

Conclusions:

  • SMU-8@W presents a promising therapeutic strategy for diabetic foot ulcers by simultaneously addressing infection and modulating the wound microenvironment.
  • This pH-regulating, infection-suppressing material promotes angiogenesis and collagen synthesis, leading to accelerated wound closure.
  • The developed fabric offers a multifunctional approach to improving healing efficiency in complex diabetic wounds.