Glucose-Driven LDH@GOx Cascade Nanozymatic Hydrogel with ROS Regulation for Bacteria-Infected Diabetic Wound Healing

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing

Background:

• Chronic diabetic wounds present challenges like high glucose, infection risk, and oxidative stress, hindering healing.
• Existing treatments struggle to dynamically manage the complex wound microenvironment.

Purpose of the Study:

• To develop a novel cascade nanozyme-hydrogel platform for intelligent management of chronic diabetic wounds.
• To address hyperglycemia, infection susceptibility, and oxidative stress for accelerated wound healing.

Main Methods:

• Integration of NiAl layered double hydroxide (LDH), glucose oxidase (GOx), and a hyaluronic acid-lipoic acid (HALA) hydrogel.
• Utilizing GOx for glucose metabolism and LDH for pH-activated antibacterial action.
• Employing HALA hydrogel for anti-inflammatory and regenerative properties.

Main Results:

• The LDH-GOx@HALA hydrogel demonstrated dynamic glucose- and pH-responsive functionality in vitro.
• In vivo studies in diabetic rat models showed accelerated wound healing via microenvironment regulation.
• The system effectively managed infection and promoted tissue regeneration.

Conclusions:

• The developed nanozyme-hydrogel platform offers a promising, environmentally benign strategy for chronic diabetic wound management.
• Exploiting pathological factors as endogenous triggers enables dynamic reconstruction of a healing-favorable microenvironment.
• This intelligent wound management approach holds potential for clinical translation.