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Related Concept Videos

Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids02:04

Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids

Diols are compounds with two hydroxyl groups. In addition to syn dihydroxylation, diols can also be synthesized through the process of anti dihydroxylation. The process involves treating an alkene with a peroxycarboxylic acid to form an epoxide. Epoxides are highly strained three-membered rings with oxygen and two carbons occupying the corners of an equilateral triangle. This step is followed by ring-opening of the epoxide in the presence of an aqueous acid to give a trans diol.
Radical Anti-Markovnikov Addition to Alkenes: Overview01:25

Radical Anti-Markovnikov Addition to Alkenes: Overview

The addition of hydrogen bromide to alkenes in the presence of hydroperoxides or peroxides proceeds via an anti-Markovnikov pathway and yields alkyl bromides.
Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride01:26

Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride

Radical substitution reactions can be used to remove functional groups from molecules. The hydrogenolysis of alkyl halides is one such reaction, where the weak Sn–H bond in tributyltin hydride reacts with alkyl halides to form alkanes. Here, the reagent Bu3SnH yields tributyltin halide as a byproduct.
The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation reactions,...
Radical Reactivity: Intramolecular vs Intermolecular01:33

Radical Reactivity: Intramolecular vs Intermolecular

Radical reactions can occur either intermolecularly or intramolecularly. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene or vice versa. In such reactions, the radical and generally the alkene, which is also called the radical trap, are two different molecules. Additionally, for such intermolecular reactions to occur, the radical trap must be active, present in an excess concentration, and the radical starting material must have a weak carbon–halogen...
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
Acid Halides to Alcohols: LiAlH4 Reduction01:19

Acid Halides to Alcohols: LiAlH4 Reduction

Acid halides are reduced to alcohols in the presence of a strong reducing agent like lithium aluminum hydride.
The mechanism proceeds in three steps. First, the nucleophilic hydride ion attacks the carbonyl carbon of the acid halide to form a tetrahedral intermediate. Next, the carbonyl group is re-formed, and the halide ion departs as a leaving group, generating an aldehyde. A second nucleophilic attack by the hydride yields an alkoxide ion, which, upon protonation, gives a primary alcohol as...

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Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
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Redox-Neutral Interstitial Hydride Incorporation in Ruddlesden-Popper Oxides.

Daichi Kato1, Shuhei Ueda1, Tong Zhu1

  • 1Department of Chemical Science and Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-Ku, Kyoto 615-8510, Japan.

Inorganic Chemistry
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a new redox-neutral method to create perovskite oxyhydrides by exchanging oxygen for hydride anions. This expands the range of functional materials, enabling exploration of properties like ion conductivity.

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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

Published on: June 20, 2014

Area of Science:

  • Materials Science
  • Solid-State Chemistry
  • Inorganic Chemistry

Background:

  • Perovskite oxyhydrides offer diverse functionalities but are limited by synthesis methods relying on cation reduction.
  • Conventional topochemical hydridation restricts the compositional space of these materials.

Purpose of the Study:

  • To introduce a novel redox-neutral topochemical route for synthesizing Ruddlesden-Popper (RP) oxyhydrides.
  • To investigate the incorporation and structural effects of hydride anions in RP frameworks.

Main Methods:

  • Employed an O2-/2H- exchange reaction for topochemical hydride insertion into rock-salt layers.
  • Synthesized SrLaScO4-x/2Hx and ALa2Sc2O7-x/2Hx (A = Sr, Ba) using the redox-stable Sc3+.

Main Results:

  • Achieved systematic hydride incorporation, yielding Sr phases (x ∼ 2.0) with unusual octahedral tilting and Ba phases (x ∼ 3.2) with higher hydride content.
  • Demonstrated site-selective hydride occupation in Sr phases governed by electrostatic interactions.
  • Correlated hydride incorporation levels with interstitial site geometry and the Goldschmidt tolerance factor in Ba phases.

Conclusions:

  • Established a versatile redox-neutral pathway for interstitial hydride incorporation in RP oxyhydrides.
  • Revealed a structural design principle for controlling hydride occupancy based on framework geometry.
  • Opened avenues for exploring new functional properties, including hydride-ion conductivity and hybrid improper ferroelectricity.