Pan-cancer screening, bioinformatics analysis, and experimental validation identify TEX10 as a key biomarker driving...

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• TEX10 is a nuclear protein implicated in chromatin remodeling.
• Its pan-cancer diagnostic, prognostic, and immunotherapeutic value requires systematic evaluation.
• The specific role of TEX10 in oral squamous cell carcinoma (OSCC) is currently unclear.

Purpose of the Study:

• To systematically evaluate the pan-cancer diagnostic, prognostic, and immunotherapeutic value of TEX10.
• To elucidate the role of TEX10 in oral squamous cell carcinoma (OSCC).
• To assess TEX10's association with the tumor immune microenvironment and its functional impact on cancer cells.

Main Methods:

• Utilized TCGA and GTEx data for pan-cancer analysis of TEX10.
• Conducted OSCC-specific clinical, diagnostic, and survival correlation analyses.
• Performed protein-protein interaction (PPI) network analysis, GO/KEGG enrichment, and in vitro assays to determine biological roles and functional effects.

Main Results:

• TEX10 was upregulated in 15 cancer types and demonstrated prognostic value across multiple cancers.
• TEX10 expression correlated with advanced clinical stage, TNM stage, and smoking history in OSCC, showing high diagnostic accuracy.
• In vitro studies revealed TEX10 knockdown suppressed cell viability, migration, invasion, and induced apoptosis and G0/G1 cell cycle arrest.

Conclusions:

• TEX10 plays a significant role in cell cycle progression in OSCC.
• TEX10 shows promise as a diagnostic and prognostic biomarker for OSCC.
• TEX10 represents a potential therapeutic target for oral squamous cell carcinoma.