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Thrombocytopenia in Pregnancy: A Narrative Review
Priyanka Garg1, Natasha Gupta2
1Department of Obstetrics and Gynaecology, Government Medical College and Hospital-Sector 32, Union Territory of Chandigarh 160030 Chandigarh, India.
Summary
Thrombocytopenia in pregnancy, a common condition, ranges from benign gestational cases to severe conditions like ITP and thrombotic microangiopathies. Early diagnosis and management are crucial for maternal and fetal well-being.
Area of Science:
- Hematology
- Obstetrics
- Perinatology
Background:
- Thrombocytopenia affects 7-12% of pregnancies.
- Gestational thrombocytopenia is common and benign.
- Other causes pose significant maternal and fetal risks.
Purpose of the Study:
- Provide a comprehensive overview of pregnancy-related thrombocytopenia.
- Emphasize differential diagnosis, workup, and management.
- Focus on conditions needing urgent intervention, like thrombotic microangiopathies.
Main Methods:
- Narrative review of literature, guidelines, and registry data.
- Emphasis on clinical applicability and trimester-wise drug safety.
- Development of proposed diagnostic algorithms.
Main Results:
- Pregnancy thrombocytopenia etiology varies from benign to life-threatening.
- Gestational thrombocytopenia is most common and requires no intervention.
- Immune thrombocytopenia (ITP) and thrombotic microangiopathies require specific therapies.
Conclusions:
- Early recognition, triage, and multidisciplinary care improve outcomes.
- Individualized treatment balances maternal benefit and fetal safety.
- Clinical tools guide evidence-based decision-making.
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