Related Experiment Video
Updated: Jun 24, 2026
07:58
Characterizing Mutational Load and Clonal Composition of Human Blood
Published on: July 11, 2019
Blurring the Lines: NPM1 Mutation in Blast Phase CML Challenges Traditional Paradigms
Smeeta Gajendra1, Leena Gupta1, Deepshi Thakral1
1Department of Laboratory Oncology, Dr. B.R.A.I.R.C.H, All India Institute of Medical Sciences, Room No. 239, Second Floor, New Delhi, 110029 India.
Summary
No abstract available in PubMed .
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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01:36Mismatch Repair
Overview
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Point mutations are genetic alterations involving the change of a single nucleotide base pair in DNA. Depending on how the alteration affects protein synthesis, they can lead to various consequences.Point mutations fall into the following types:Silent mutations occur when a nucleotide change does not alter the amino acid sequence due to the redundancy of the genetic code. For instance, changing ACC to ACA still encodes threonine, leaving the protein function unaffected. This occurs because...