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Related Experiment Video

Updated: Jun 24, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

Plasma Cell Morphology: Many Faces, One Essence.

Iffat Jamal¹, Shuchismita¹

¹Department of Pathology (Hematology section), Indira Gandhi Institute of Medical Sciences, Patna, India.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion

|June 23, 2026

Summary

Plasma cells show varied forms, from typical to atypical, complicating diagnoses. Integrating morphology with clinical data is key for accurate plasma cell disorder diagnosis.

Keywords:

Morphology Multiple myeloma Plasma cell

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Last Updated: Jun 24, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

Area of Science:

Hematology
Pathology
Cell Biology

Background:

Plasma cells display a wide range of morphologies, including mature, atypical, and anaplastic forms.
This morphological diversity presents diagnostic challenges, especially in differentiating reactive conditions from neoplastic plasma cell disorders.

Purpose of the Study:

To delineate the spectrum of plasma cell morphology.
To emphasize the critical role of integrating morphological assessment with clinical and laboratory findings for accurate diagnosis.

Main Methods:

Review of plasma cell morphology across various conditions.
Correlation of morphological features with clinical presentations and laboratory results.

Main Results:

Observed significant heterogeneity in plasma cell morphology.
Demonstrated that distinguishing reactive from neoplastic processes requires a multi-faceted diagnostic approach.

Conclusions:

Accurate diagnosis of plasma cell disorders relies on a comprehensive evaluation, combining detailed morphological analysis with clinical context and laboratory data.
Understanding the morphological spectrum is crucial for pathologists and hematologists in managing plasma cell-related conditions.