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Comparison of postoperative complications following CABG in diabetic and non-diabetic patients

Akram Ghadiri-Anari1, Farnaz Bemaninejad2, Seyedeh Mahdieh Namayandeh3

  • 1Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

ARYA Atherosclerosis
|June 23, 2026
PubMed

Insights

Diabetic patients undergoing coronary artery bypass grafting (CABG) showed similar short-term complication rates to non-diabetic patients. However, diabetes was linked to a higher incidence of seizures post-CABG, requiring further study.

Area of Science:

  • Cardiovascular Surgery
  • Diabetology
  • Clinical Outcomes Research

Background:

  • Diabetic patients have a higher risk of cardiovascular disease, often necessitating coronary artery bypass grafting (CABG).
  • Existing evidence on post-CABG outcomes in diabetic versus non-diabetic individuals is inconsistent.
  • Limited data exists for the Iranian population regarding this comparison.

Purpose of the Study:

  • To compare short-term postoperative complications following CABG between diabetic and non-diabetic patients.
  • To investigate the independent predictive value of diabetes mellitus for adverse outcomes after CABG.

Main Methods:

  • Retrospective cohort study utilizing data from the Yazd Cardiovascular Disease Registry (YCDR) (2017-2018).
  • Analysis of 1286 patients undergoing CABG, stratified into diabetic (n=592) and non-diabetic (n=694) groups.
  • Collection of data on demographics, comorbidities, and major in-hospital complications including reoperation, mortality, infections, renal, neurological, and pulmonary issues.

Main Results:

  • Diabetic patients exhibited higher frequencies of female sex, hypertension, and hyperlipidemia (p<0.001).
  • No significant differences were found in the incidence of major complications like reoperation (2.1% vs. 2.3%) and mortality (3.2% vs. 2.4%) between groups (p>0.05).
  • Seizures occurred exclusively in the diabetic group (1.1% vs. 0%; p=0.049), and diabetes was not an independent predictor of overall complications.

Conclusions:

  • Diabetes mellitus was not identified as an independent risk factor for most short-term post-CABG complications in this cohort.
  • A higher incidence of seizures was observed in diabetic patients post-CABG, necessitating further investigation into underlying mechanisms.
  • Larger prospective studies are recommended to validate these findings and explore specific diabetic complications.
Abstract

Keywords:
Coronary Artery BypassDiabetes MellitusLogistic ModelsPostoperative ComplicationsSeizures

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