Related Experiment Video
Updated: Jun 24, 2026
06:34
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Allergen Sensitization Profiles and Co-Sensitization Networks in Children with Allergic Rhinitis and Asthma: A
Pinli Zou1, Yinghong Fan1, Cheng Xie1
1Pediatric Respiratory Medicine Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Journal of Asthma and Allergy
|June 23, 2026
Summary
Asthma in children involves a more complex allergen cross-sensitization network than allergic rhinitis. Delayed food sensitization resolution is key to identifying asthma, emphasizing food allergy monitoring in pediatric airway disease.
Area of Science:
- Allergen sensitization patterns in pediatric allergic airway diseases.
- Immunological mechanisms linking allergic rhinitis to asthma.
- Network analysis of co-sensitization in respiratory allergies.
Background:
- Mechanisms driving allergic airway disease progression from allergic rhinitis (AR) to asthma (AS) in children are not fully understood.
- This study investigates age-related patterns and network heterogeneity of allergen sensitization between AR and AS phenotypes.
Purpose of the Study:
- To investigate age-related patterns in allergen sensitization.
- To analyze the topological network heterogeneity of allergen co-sensitization in children with AR versus AS.
- To identify independent risk factors for lower airway involvement.
Main Methods:
- Retrospective cross-sectional study of 2193 children with AR or AS.
- Propensity score matching (PSM) created a 1:1 matched cohort of 1206 patients.
- Ising probability graphical model for topological architecture of allergen co-sensitization; multivariable logistic regression for risk factors.
Main Results:
- Inhalant sensitization increased homogenously with age in both groups; foodborne immune tolerance showed heterogeneity.
- Adolescents (≥12 years) with AS had significantly higher sensitization risk to milk (5.64-fold) and egg white (3.40-fold) compared to AR.
- AS network analysis revealed high complexity and cross-system connectivity, with peanut as a hub; cockroach and peanut sensitization were independent risk factors for lower airway involvement.
Conclusions:
- Children with AS exhibit a more complex cross-sensitization network than those with AR.
- Delayed resolution of food sensitizations differentiates the AS phenotype.
- Monitoring food allergies is crucial for managing pediatric airway diseases.
Related Concept Videos
02:06Allergic Reactions
Overview
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:30Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...