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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

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Effectiveness of Multiple Platelet-Rich Plasma Injections for Olfactory Dysfunction.

Jerome R Lechien1,2,3,4,5, Sven Saussez2,5

  • 1Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-Rhino-Laryngologie Et De Chirurgie Cervico-Faciale
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Multiple platelet-rich plasma (PRP) injections significantly improve olfactory function in patients with olfactory dysfunction (OD). This study evaluated PRP

Keywords:
olfactory dysfunctionotolaryngologyotorhinolaryngologyplatelet-rich plasmarhinology

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Area of Science:

  • Otolaryngology
  • Regenerative Medicine
  • Olfactory Neuroscience

Background:

  • Olfactory dysfunction (OD) impacts quality of life, with limited effective treatments.
  • Platelet-rich plasma (PRP) injections are an emerging therapy for OD.
  • The efficacy of multiple PRP injections for OD has not been previously studied.

Purpose of the Study:

  • To assess the effectiveness and utility of multiple PRP injections in the olfactory clefts for patients with OD.
  • To evaluate dose-response relationships and identify predictors of treatment success.

Main Methods:

  • A prospective controlled study involving 83 patients with long-lasting OD (anosmia, hyposmia, parosmia).
  • Participants received two PRP injections into the olfactory clefts at 4- to 6-month intervals.
  • Olfactory function was measured using threshold, discrimination, and identification (TDI) testing; minimal clinically important difference (MCID) was assessed.

Main Results:

  • Transient epistaxis was the most common adverse event (46.2%).
  • TDI scores significantly improved after both the first and second PRP injections across all OD subgroups.
  • MCID was achieved in 75.9% of patients from baseline to final evaluation; baseline TDI strongly predicted post-injection scores.

Conclusions:

  • Two PRP injections demonstrate significant improvements in psychophysical olfactory function for patients with OD.
  • The study highlights the potential of PRP therapy but calls for further research.
  • Future studies should determine optimal injection protocols and identify predictors for therapeutic effectiveness.