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Effectiveness of Multiple Platelet-Rich Plasma Injections for Olfactory Dysfunction.
Jerome R Lechien1,2,3,4,5, Sven Saussez2,5
1Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.
Summary
Multiple platelet-rich plasma (PRP) injections significantly improve olfactory function in patients with olfactory dysfunction (OD). This study evaluated PRP
Area of Science:
- Otolaryngology
- Regenerative Medicine
- Olfactory Neuroscience
Background:
- Olfactory dysfunction (OD) impacts quality of life, with limited effective treatments.
- Platelet-rich plasma (PRP) injections are an emerging therapy for OD.
- The efficacy of multiple PRP injections for OD has not been previously studied.
Purpose of the Study:
- To assess the effectiveness and utility of multiple PRP injections in the olfactory clefts for patients with OD.
- To evaluate dose-response relationships and identify predictors of treatment success.
Main Methods:
- A prospective controlled study involving 83 patients with long-lasting OD (anosmia, hyposmia, parosmia).
- Participants received two PRP injections into the olfactory clefts at 4- to 6-month intervals.
- Olfactory function was measured using threshold, discrimination, and identification (TDI) testing; minimal clinically important difference (MCID) was assessed.
Main Results:
- Transient epistaxis was the most common adverse event (46.2%).
- TDI scores significantly improved after both the first and second PRP injections across all OD subgroups.
- MCID was achieved in 75.9% of patients from baseline to final evaluation; baseline TDI strongly predicted post-injection scores.
Conclusions:
- Two PRP injections demonstrate significant improvements in psychophysical olfactory function for patients with OD.
- The study highlights the potential of PRP therapy but calls for further research.
- Future studies should determine optimal injection protocols and identify predictors for therapeutic effectiveness.
