Phytocompound-loaded Biomaterial-based Scaffolds: Emerging Strategies for Wound Healing Applications.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Pharmacology

Background:

• Effective wound healing requires controlled inflammation, vascularization, and organized extracellular matrix deposition.
• Scaffold-based therapies offer structural support and act as delivery carriers for wound healing.
• Phytocompounds possess beneficial wound healing properties but suffer from poor bioavailability.

Purpose of the Study:

• To review modern wound healing strategies focusing on scaffold-based therapies.
• To analyze the incorporation of phytocompounds into various scaffold formats.
• To highlight the synergistic potential of phytocompound-loaded scaffolds for advanced wound healing.

Main Methods:

• Comprehensive literature review of scaffold-based wound healing strategies.
• Critical analysis of phytocompound incorporation into diverse scaffold types (hydrogels, nanofibers, sponges, films, 3D-printed).
• Evaluation of preclinical evidence for phytocompound-loaded scaffolds in wound repair.

Main Results:

• Phytocompounds exhibit pro-angiogenic, antioxidant, anti-inflammatory, and antimicrobial effects beneficial for wound healing.
• Incorporating phytocompounds into scaffolds overcomes their limitations of low solubility, poor stability, and rapid degradation.
• Phytocompound-loaded scaffolds demonstrate enhanced wound healing activities in preclinical studies.

Conclusions:

• Biomaterial scaffolds combined with phytocompounds create advanced wound healing systems.
• Phytocompound-loaded scaffolds accelerate wound repair, showing potential as next-generation therapeutics.
• Further research is needed to address challenges for clinical translation of these scaffolds.