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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Serum Neuroglobin in Acute Traumatic Brain Injury in Children: A Multicenter Case-Control Study.

Khaled Saad1, Hala S M Abdelmotogaly2, Amira H El-Ashry3

  • 1Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.

Neurosurgery
|June 23, 2026
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Summary
This summary is machine-generated.

Serum neuroglobin levels rise in children after traumatic brain injury (TBI), peaking at 24 hours. Higher levels correlate with TBI severity and predict poor outcomes, aiding early risk assessment.

Keywords:
BiomarkerNeuroglobinPediatricsPrognosisSerumTraumatic brain injury

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Area of Science:

  • Pediatric neurology
  • Biomarker research
  • Trauma care

Background:

  • Traumatic brain injury (TBI) is a major cause of death and disability in children.
  • Early identification of TBI severity and prognosis is crucial for effective management.
  • Neuroglobin, an oxygen-binding protein, is implicated in neuroprotection.

Purpose of the Study:

  • To investigate the temporal changes of serum neuroglobin in pediatric TBI patients.
  • To assess neuroglobin's utility as a biomarker for TBI severity.
  • To evaluate neuroglobin's predictive value for clinical outcomes in children post-TBI.

Main Methods:

  • A multicenter case-control study involving 110 children with TBI and 100 healthy controls.
  • Serum neuroglobin measured by ELISA at admission, 24 hours, and 72 hours post-TBI.
  • Analysis of neuroglobin kinetics against Glasgow Coma Scale scores and 6-month Glasgow Outcome Scale.

Main Results:

  • Serum neuroglobin was significantly elevated in TBI children compared to controls.
  • Neuroglobin levels peaked at 24 hours post-TBI and decreased by 72 hours.
  • Peak neuroglobin inversely correlated with Glasgow Coma Scale scores and predicted poor 6-month outcomes (AUC=0.89).

Conclusions:

  • Serum neuroglobin is a potential early prognostic biomarker for pediatric TBI.
  • Its dynamic changes and correlation with severity support its role in risk stratification.
  • Neuroglobin shows promise for predicting functional outcomes in children after TBI.