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Related Experiment Video

Updated: Jun 24, 2026

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse

Published on: April 17, 2019

Magnetic Resonance Imaging-Based Psoas Muscle Volume as an Additional Risk Factor for Fontan Failure: A Prospective

Sukran Erdem¹, Tarique Hussain^1,2,3, Orhan Erdem⁴

¹Division of Pediatric Cardiology Children's Health-University of Texas Southwestern Medical Center Dallas TX USA.

Journal of the American Heart Association

|June 23, 2026

Summary

Psoas muscle volume (PMV) better identifies sarcopenia in Fontan circulation patients than psoas muscle area (PMA). PMV offers prognostic value for Fontan failure, unlike PMA.

Keywords:

Fontan magnetic resonance psoas muscle sarcopenia

Related Experiment Videos

Last Updated: Jun 24, 2026

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse

Published on: April 17, 2019

Area of Science:

Cardiology
Radiology
Muscle Physiology

Background:

Sarcopenia is common in Fontan circulation, impacting function and outcomes.
Psoas muscle area (PMA) is a common but potentially limited measure of sarcopenia.
Psoas muscle volume (PMV) may offer a more accurate assessment of muscle mass.

Purpose of the Study:

Compare PMA and PMV in differentiating Fontan patients from controls.
Assess the prognostic value of PMA and PMV in Fontan circulation.
Determine if PMV provides incremental prognostic information beyond clinical factors.

Main Methods:

Prospective study quantifying PMA and PMV using MRI in 70 Fontan patients and 51 controls.
Muscle metrics were indexed to body surface area.
Multivariable logistic regression analyzed associations with Fontan failure.

Main Results:

Male Fontan patients showed lower indexed PMV and PMA than controls.
Indexed PMV, but not PMA, modestly improved prediction of Fontan failure when added to a clinical model.
Fontan-associated liver disease, low serum total protein, and low oxygen saturation predicted Fontan failure.

Conclusions:

Indexed PMV may serve as an imaging biomarker for sarcopenia in Fontan circulation.
PMV shows potential for incremental prognostic information in Fontan patients.
Further validation of PMV's predictive value in larger cohorts is warranted.