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Updated: Jun 24, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
An Acceptor-Donor-Acceptor Semiconductor Conjugated Polymer-Based Composite Hydrogel for Photothermal/Photodynamic
Kenong Li1, Kunyi Wang1, Guoyang Zhang2
1State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China.
Abstract:
Bacterial infections impede wound healing and are exacerbated by antibiotic resistance. In this study, three semiconductor conjugated polymer (SCP) nanomaterials (DFPE, DTBA, and DTID) with integrated photodynamic/photothermal therapeutic functions are developed by employing different electron donor groups. Compared to DFPE and DTBA, the introduction of a benzo[e]indole unit endows DTID with a distinct A-D-A electronic configuration. DTID exhibits strong near-infrared absorption, excellent photothermal conversion efficiency (38.4%), and efficient reactive oxygen species (ROS) generation. Furthermore, the composite hydrogel HGJD is constructed by coloading DTID and curcumin into a sodium alginate/chitosan hydrogel. HGJD integrated the hydrogel's inherent moisturizing capacity and biocompatibility, DTID's dual phototherapy, and curcumin's antioxidant and anti-inflammatory activities. HGJD effectively kills Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and exhibits antioxidant activity. In the S. aureus-infected mouse model, HGJD with light irradiation eliminates bacteria, reduces inflammation, and accelerates wound healing. This work presents a promising strategy for designing hydrogel dressings with dual phototherapy and anti-inflammatory functions.
