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Colony Stimulating Factor-1 Receptor-Related Disorder Treated With Ilunazebart
Lukasz Milanowski1,2, Delaney Liskey3,4, Audrey J Strongosky1
1Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
This case study of Colony stimulating factor-1 receptor-related disorder (CSF1R-RD) found that the TREM2 agonist iluzanebart did not improve clinical, radiological, or neuropathological outcomes in a patient with advanced disease.
Area of Science:
- Neuroscience
- Genetics
- Pathology
Background:
- Colony stimulating factor-1 receptor-related disorder (CSF1R-RD) is a rare, autosomal dominant neurodegenerative disease characterized by microglial dysfunction and white matter degeneration.
- Therapeutic strategies targeting microglial pathways, such as TREM2 activation, are being explored to counteract impaired CSF1R signaling.
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