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Related Concept Videos

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

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Updated: Jun 24, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
07:50

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Published on: May 26, 2019

DMSO as a multifunctional reactant in recent organic synthesis.

Anil Rangnath Pawar1, Arnab Mandal1, Abu Taleb Khan1

  • 1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India. atk@iitg.ac.in.

Organic & Biomolecular Chemistry
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Dimethyl sulfoxide (DMSO) is a versatile reagent in organic synthesis, acting as a source for carbon, sulfur, and oxygen. This review highlights its use as a synthon for creating novel chemical compounds.

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Area of Science:

  • Organic Chemistry
  • Sustainable Chemistry
  • Sulfur Chemistry

Background:

  • Dimethyl sulfoxide (DMSO) is a widely used eco-friendly solvent and oxidant in organic synthesis.
  • DMSO offers unique properties as a source of carbon, sulfur, and oxygen atoms.
  • Its role in constructing chemical bonds is a key area of modern synthetic chemistry.

Purpose of the Study:

  • To systematically review and categorize recent advancements in using DMSO as a synthon.
  • To focus on DMSO's application as a single-, dual-, or multiple-atom building block.
  • To underscore the significance of DMSO in organic sulfur chemistry and the synthesis of novel compounds.

Main Methods:

  • Literature review and systematic compilation of recent studies.
  • Categorization of DMSO's synthetic applications based on its role as a synthon.
  • Analysis of DMSO's utility in forming carbon-carbon and carbon-heteroatom bonds.

Main Results:

  • DMSO serves as a versatile source of C, S, and O atoms in organic transformations.
  • Numerous examples demonstrate DMSO's application as a single-, dual-, or multiple-atom synthon.
  • These applications lead to the efficient construction of diverse chemical entities.

Conclusions:

  • DMSO is a pivotal reagent in sustainable organic synthesis, enabling efficient bond formation.
  • Its multifaceted role as a synthon represents a significant advancement in organic sulfur chemistry.
  • The use of DMSO facilitates the creation of new molecules with potential biological relevance.