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Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
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Published on: March 11, 2022

Cellular Heterogeneity During Arterial Aging.

He Xu1, Paul-Lennard Mendez1,2,3, Dimitri Kasakovski1,4

  • 1Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.

Aging Cell
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Arterial aging, a risk factor for cardiovascular disease, involves cellular changes like senescence and inflammation. Single-cell RNA sequencing reveals these age-related vascular alterations across different cell types.

Keywords:
arterial agingcellular senescencecell–cell communicationextracellular matrix remodelinginflammagingsingle‐cell RNA sequencingvascular heterogeneity

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Area of Science:

  • Vascular Biology
  • Aging Research
  • Cardiovascular Disease

Background:

  • Arterial aging contributes to cardiovascular disease through structural and functional changes.
  • Key aging hallmarks include arterial stiffening, inflammation, and senescence.
  • Single-cell RNA sequencing (scRNA-seq) offers insights into arterial wall cellular heterogeneity during aging.

Purpose of the Study:

  • To review current scRNA-seq studies on arterial aging.
  • To identify key cellular phenotypes and programs in aged arteries.
  • To discuss cell-intrinsic and intercellular communication changes in vascular aging.

Main Methods:

  • Comprehensive review of single-cell RNA sequencing studies on arterial aging.
  • Focus on phenotypic programs: senescence, matrix remodeling, inflammaging, and communication.
  • Analysis of age-related changes in endothelial cells, smooth muscle cells, fibroblasts, and immune cells.

Main Results:

  • Aging is linked to endothelial dysfunction, smooth muscle cell modulation, fibroblast matrix remodeling, and immune activation.
  • Cellular changes vary by species, vascular bed, sex, and disease context.
  • Vascular aging involves cell-intrinsic changes and altered intercellular communication networks.

Conclusions:

  • scRNA-seq has advanced understanding of arterial aging's cellular basis.
  • Limitations include inconsistent annotations, incomplete validation, and limited spatial/epigenetic data.
  • Future research integrating multi-omics and functional studies is crucial for translational relevance.