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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Related Experiment Video

Updated: Jun 24, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Published on: January 30, 2026

An Aging Clock Based on Immune Repertoire Features: COVID-19 Accelerates Aging.

Xin Gao1,2, Si-Jia Li1,3, Jin Li1

  • 1The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Aging Cell
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Aging reshapes T/B cell receptor repertoires, decreasing diversity and altering immune cell function. COVID-19 intensifies these age-related immune changes, impacting long-term health and recovery.

Keywords:
COVID‐19agingimmune repertoiremachine learning

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Last Updated: Jun 24, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

Area of Science:

  • Immunology
  • Gerontology
  • Genomics

Background:

  • Aging leads to immunosenescence, increasing vulnerability to infections.
  • T/B cell receptor (TCR/BCR) repertoire changes with age are not fully understood, especially in diverse populations.
  • The impact of SARS-CoV-2 on immune repertoire aging requires further investigation.

Purpose of the Study:

  • To characterize T/B cell receptor repertoire remodeling during aging in Chinese individuals.
  • To investigate the exacerbating effects of COVID-19 on immune repertoire aging.
  • To develop and validate an immune repertoire aging clock.

Main Methods:

  • High-throughput sequencing of CDR3 regions from leukocyte DNA of healthy Chinese individuals and post-COVID-19 cases.
  • Analysis of TCR/BCR repertoire diversity, clonotype counts, and gene usage.
  • Development of a LightGBM-based machine learning model for immune age prediction.

Main Results:

  • Aging correlated with reduced TCR/BCR diversity, shorter CDR3 sequences, and altered clonotype composition, with a critical turning point around 60 years.
  • Post-COVID-19 cases showed intensified repertoire aging, including altered amino acid usage and expanded pathogen-related clones.
  • The developed immune aging clock validated accelerated biological aging and reduced intrinsic capacity in post-COVID-19 individuals.

Conclusions:

  • Age-dependent remodeling of the immune repertoire is significant and influenced by factors like COVID-19.
  • COVID-19 exacerbates immunosenescence, potentially contributing to post-viral dysfunction.
  • Findings offer insights into immunosenescence and post-COVID-19 syndromes, with potential clinical applications.