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Intravitreous Injection for Establishing Ocular Diseases Model
Published on: October 1, 2007
Novel Vitreous Substitutes in Animal and Human Models: A Systematic Review
Danielle Solish1, Lia Huo2, Tony Shicheng Jin3
1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada, utoronto.ca.
Biomed Research International
|June 23, 2026
Summary
Novel vitreous substitutes show promise for retinal surgery, offering improved optical clarity and biocompatibility compared to current options. Further investigation is warranted for these advanced materials in clinical applications.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Retinal Surgery
Background:
- Current vitreous substitutes used in vitreoretinal surgery have limitations, including reduced visual acuity and potential complications like glaucoma and cataract.
- These limitations necessitate the development of improved vitreous substitutes for better patient outcomes.
Purpose of the Study:
- To systematically review and evaluate the biological, physical, and clinical properties of novel experimental vitreous substitutes.
- To identify promising candidates for future vitreoretinal surgical applications.
Main Methods:
- A systematic literature search was conducted across Ovid Medline, Embase, and Scopus databases.
- Studies published between January 1, 1990, and October 10, 2025, reporting on optical properties, biological interactions, or clinical outcomes were included.
- 37 studies investigating hydrogels, polymers, liquids, and devices were analyzed.
Main Results:
- 16/37 novel substitutes demonstrated over 80% success in retinal detachment tamponade.
- 12/37 substitutes exhibited high tissue biocompatibility and 15/37 showed low ocular inflammation.
- 13/37 substitutes possessed optical properties comparable to native vitreous, with 14/37 showing no significant intraocular pressure changes.
Conclusions:
- Novel experimental vitreous substitutes demonstrate significant potential for vitreoretinal surgery.
- Specific candidates like UV-CHA, Vitargus ABV-1701, PanaceaGel SPG-178, E10KDC18, and FCVB warrant further investigation.
- These substitutes offer promising biological, optical, and physical characteristics for enhanced surgical outcomes.
