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Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview

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Related Experiment Video

Updated: Jun 24, 2026

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Brain-on-a-Chip and Blood-Brain Barrier-on-a-Chip Modeling for Neurodegenerative Disorders: Recent Progress.

Duraisamy Kempuraj1, Huachen Shi1, Travis D Truong1

  • 1Institute for Neuro-Immune Medicine, Center of Excellence for Neuroinflammation Research, Dr Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|June 23, 2026
PubMed
Summary

Brain-on-a-chip and blood-brain barrier (BBB)-on-a-chip platforms model neurological diseases. These advanced systems aid in understanding disease mechanisms and developing new neurotherapeutics for challenging brain disorders.

Keywords:
brain-on-a-chipinduced pluripotent stem cellsmicroelectrode arraysneurodegenerative diseasesneurovascular unit

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A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

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Last Updated: Jun 24, 2026

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
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Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
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Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

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A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
07:52

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

Area of Science:

  • Neuroscience
  • Biotechnology
  • Biomedical Engineering

Background:

  • The blood-brain barrier (BBB) is crucial for brain homeostasis, but its dysfunction contributes to neuroinflammation and neurodegenerative diseases.
  • Understanding BBB disruption mechanisms is vital for developing effective neurotherapeutics.
  • Current challenges include the poor understanding of BBB mechanisms and the difficulty of drug delivery across the BBB.

Purpose of the Study:

  • To review recent advances in brain-on-a-chip and BBB-on-a-chip technologies.
  • To highlight the potential of these platforms in studying neurodegenerative disease pathogenesis.
  • To explore their applications in preclinical drug screening for neurological disorders.

Main Methods:

  • Utilizing microfluidic platforms to create BBB-on-a-chip systems that mimic the human BBB.
  • Integrating microelectrode arrays for real-time monitoring of neuronal activity and network behavior.
  • Employing induced pluripotent stem cell-derived cells from healthy individuals and patients.

Main Results:

  • Microfluidic BBB-on-a-chip systems replicate key structural and functional aspects of the human BBB under dynamic flow.
  • Integration with microelectrode arrays enables high-throughput drug screening and targeted delivery.
  • Progress has been made using stem cell-derived cells from various neurological disease backgrounds.

Conclusions:

  • Brain- and BBB-on-a-chip technologies represent significant progress in modeling brain disorders.
  • These platforms offer powerful tools for investigating disease pathogenesis and evaluating potential neurotherapeutics.
  • Further development holds promise for advancing the treatment of neurodegenerative diseases.