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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: Jun 24, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Fast Progressors in Primary Open-Angle Glaucoma: A 5-Year Visual Field Index-Based Classification in a Real-World

Chengjie Feng1,2, Jing Sun1,2, Tingting Liu1,2

  • 1Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

Ophthalmology and Therapy
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Visual Field Index (VFI) helps identify fast glaucoma progression, especially in advanced stages. Incorporating VFI into routine care can better detect patients at risk of significant vision loss.

Keywords:
Disease progressionGlaucomaLinear modelsLongitudinal studiesOpen-angleVisual field tests

Related Experiment Videos

Last Updated: Jun 24, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Visual Field Analysis

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Early detection of disease progression is crucial for timely intervention.
  • Visual field testing is a key method for monitoring glaucoma.

Purpose of the Study:

  • To evaluate the Visual Field Index (VFI) for identifying fast progressors in POAG.
  • To analyze risk factors associated with rapid visual field decline.
  • To compare VFI-based progression criteria with Mean Deviation (MD).

Main Methods:

  • Defined fast progression as VFI decline > -4.6%/year or MD decline > -1 dB/year.
  • Defined moderately rapid progression (MRP) using cohort-derived cutoffs.
  • Employed linear mixed-effects models (LMM) to analyze longitudinal VFI changes.

Main Results:

  • VFI indicated a fast progression rate of 0.92%, while MD showed 2.75%.
  • VFI-defined MRP increased significantly with disease stage (p < 0.001).
  • Worse baseline MD, thinner cornea, lower spherical equivalent, and older age predicted steeper VFI decline.

Conclusions:

  • VFI-defined fast progression was infrequent in this POAG cohort.
  • VFI criteria demonstrated significant stage-dependent discrimination of progression.
  • Longitudinal VFI modeling in routine care can improve identification of high-risk eyes.