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Updated: Jun 24, 2026
07:11
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Fast Progressors in Primary Open-Angle Glaucoma: A 5-Year Visual Field Index-Based Classification in a Real-World
Chengjie Feng1,2, Jing Sun1,2, Tingting Liu1,2
1Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Ophthalmology and Therapy
|June 23, 2026
Summary
Visual Field Index (VFI) helps identify fast glaucoma progression, especially in advanced stages. Incorporating VFI into routine care can better detect patients at risk of significant vision loss.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Visual Field Analysis
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Early detection of disease progression is crucial for timely intervention.
- Visual field testing is a key method for monitoring glaucoma.
Purpose of the Study:
- To evaluate the Visual Field Index (VFI) for identifying fast progressors in POAG.
- To analyze risk factors associated with rapid visual field decline.
- To compare VFI-based progression criteria with Mean Deviation (MD).
Main Methods:
- Defined fast progression as VFI decline > -4.6%/year or MD decline > -1 dB/year.
- Defined moderately rapid progression (MRP) using cohort-derived cutoffs.
- Employed linear mixed-effects models (LMM) to analyze longitudinal VFI changes.
Main Results:
- VFI indicated a fast progression rate of 0.92%, while MD showed 2.75%.
- VFI-defined MRP increased significantly with disease stage (p < 0.001).
- Worse baseline MD, thinner cornea, lower spherical equivalent, and older age predicted steeper VFI decline.
Conclusions:
- VFI-defined fast progression was infrequent in this POAG cohort.
- VFI criteria demonstrated significant stage-dependent discrimination of progression.
- Longitudinal VFI modeling in routine care can improve identification of high-risk eyes.
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