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Related Concept Videos

FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
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Drug Regulation

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
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Related Experiment Video

Updated: Jun 24, 2026

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

Relacorilant: First Approval.

Hannah A Blair1

  • 1Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. dru@adis.com.

Drugs
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Relacorilant is now approved for platinum-resistant ovarian cancer. This selective glucocorticoid receptor II antagonist offers a new treatment option for patients who have not responded to prior therapies.

Related Experiment Videos

Last Updated: Jun 24, 2026

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Relacorilant (LIFYORLI™) is a novel non-steroidal, selective glucocorticoid receptor II (GR II) antagonist.
  • It is under development by Corcept Therapeutics for treating solid tumors and Cushing syndrome.

Purpose of the Study:

  • To summarize the development milestones of relacorilant.
  • To highlight its first approval for platinum-resistant ovarian, fallopian tube, and peritoneal cancers.

Main Methods:

  • Review of relacorilant's development pathway.
  • Analysis of clinical trial data leading to regulatory approval.

Main Results:

  • Relacorilant received its first US approval on March 25, 2026.
  • Approved in combination with nab-paclitaxel for specific ovarian cancer patients.

Conclusions:

  • Relacorilant's approval marks a significant advancement in treating platinum-resistant ovarian cancers.
  • This milestone provides a new therapeutic option for patients with limited treatment alternatives.