Relacorilant: First Approval

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Updated: Jun 24, 2026

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08:36

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Published on: April 7, 2023

Hannah A Blair1

  • 1Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. dru@adis.com.

Drugs
|June 23, 2026
PubMed

Insights

Relacorilant is now approved for platinum-resistant ovarian cancer. This selective glucocorticoid receptor II antagonist offers a new treatment option for patients who have not responded to prior therapies.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Relacorilant (LIFYORLI™) is a novel non-steroidal, selective glucocorticoid receptor II (GR II) antagonist.
  • It is under development by Corcept Therapeutics for treating solid tumors and Cushing syndrome.

Purpose of the Study:

  • To summarize the development milestones of relacorilant.
  • To highlight its first approval for platinum-resistant ovarian, fallopian tube, and peritoneal cancers.

Main Methods:

  • Review of relacorilant's development pathway.
  • Analysis of clinical trial data leading to regulatory approval.

Main Results:

  • Relacorilant received its first US approval on March 25, 2026.
  • Approved in combination with nab-paclitaxel for specific ovarian cancer patients.

Conclusions:

  • Relacorilant's approval marks a significant advancement in treating platinum-resistant ovarian cancers.
  • This milestone provides a new therapeutic option for patients with limited treatment alternatives.

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