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Updated: Jun 24, 2026

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Maternal Cardiovascular Health During Pregnancy and Offspring Developmental Delay.

Hisashi Ohseto¹, Mami Ishikuro^2,3, Geng Chen²

¹Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan.

JAMA Network Open

|June 23, 2026

Summary

This summary is machine-generated.

Better maternal cardiovascular health (CVH) during pregnancy is linked to a reduced risk of developmental delay in children. This study highlights the importance of maternal health for child development outcomes.

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Area of Science:

Public Health
Pediatrics
Cardiology

Background:

Developmental delay impacts children's daily living, social functioning, and mental health.
Maternal cardiovascular health (CVH) during pregnancy may influence the intrauterine environment, but its link to offspring development is not fully understood.

Purpose of the Study:

To investigate the association between maternal cardiovascular health (CVH) during pregnancy and developmental delay in offspring at 4 years of age.

Main Methods:

A cohort study analyzed 8,238 mother and offspring pairs from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan.
Maternal CVH was assessed using Life's Essential 8 metrics, categorizing mothers into high, moderate, or low CVH groups.
Offspring developmental delay at age 4 was evaluated using the Ages and Stages Questionnaire, Third Edition.

Main Results:

Mothers with moderate (RR, 1.30) and low (RR, 1.62) CVH had a higher risk of offspring developmental delay compared to those with high CVH.
Low maternal CVH was associated with increased developmental delay across all 5 assessed domains, particularly in personal-social skills (RR, 2.23).

Conclusions:

Improved maternal cardiovascular health during pregnancy is associated with a decreased risk of developmental delay in children.
These findings underscore the significance of promoting maternal cardiovascular health for optimal child neurodevelopment.