Related Experiment Video
Updated: Jun 25, 2026
07:13
Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
Correlation of Prostate Tumor Laterality with Pelvic Lymph Node Metastasis Patterns: A Retrospective Observational
Navid Masoumi1, Amir Alinejad Khorram2, Masoud Beheshti3
1Department of Urology, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urologia Internationalis
|June 23, 2026
Summary
This study found a significant correlation between prostate cancer laterality and pelvic lymph node involvement. Understanding this spatial concordance may help personalize treatments and reduce complications from lymph node dissection.
Area of Science:
- Urology
- Oncology
- Surgical Pathology
Background:
- Spatial concordance between prostate tumor side and lymphatic spread is not well understood.
- Current treatments for prostate cancer, including lymph node dissection, can cause significant morbidity.
- Individualized treatment planning requires a better understanding of prostate cancer's metastatic patterns.
Purpose of the Study:
- To investigate the correlation between the dominant side of an intraprostatic lesion and the laterality of pelvic lymph node involvement.
- To determine if laterality of prostate cancer predicts lymphatic dissemination patterns.
Main Methods:
- Retrospective review of 401 patients undergoing radical prostatectomy and extended pelvic lymph node dissection.
- Data collected included demographics, prostate-specific antigen (PSA) levels, ISUP grade, and lymph node status.
- Statistical analysis was performed to assess correlations.
Main Results:
- Pelvic lymph node involvement was observed in 12% of patients (48/401).
- Higher PSA levels and ISUP grade groups were significantly associated with nodal involvement (P<0.0001).
- A statistically significant correlation was found between the dominant side of prostate cancer and the side of pelvic lymph node involvement (P=0.04).
Conclusions:
- Higher PSA and ISUP grade predict a greater likelihood of lymph node involvement.
- A significant correlation exists between prostate cancer laterality and pelvic lymph node involvement laterality.
- These preliminary findings require further validation for clinical application.
