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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Ultrasound Cyclo Plasty in Eyes with Glaucoma
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Nocturnal Intraocular Pressure Monitoring With a Soft Contact Lens Sensor for Glaucoma Management.

Yumin Dai1, Tristan Michael Long2, Oluwabunmi T Oladele3

  • 1School of Materials Engineering, Purdue University, West Lafayette, IN, USA.

Advanced Materials (Deerfield Beach, Fla.)
|June 23, 2026
PubMed
Summary

A new soft contact lens sensor accurately measures nocturnal intraocular pressure (IOP) during sleep at home. This wearable device overcomes limitations of previous sensors, enabling better glaucoma management.

Keywords:
glaucoma managementintraocular pressure monitoringnocturnal monitoringsmart contact lenses

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Wearable Technology

Background:

  • Nocturnal intraocular pressure (IOP) monitoring is crucial for glaucoma management.
  • Existing wearable sensors have limitations in sensitivity, closed-eye performance, and overnight wearability for accurate sleep IOP assessment.

Purpose of the Study:

  • To develop a soft contact lens sensor for continuous, at-home monitoring of nocturnal IOP.
  • To improve upon existing wearable IOP sensors for enhanced accuracy and wearability during sleep.

Main Methods:

  • Integration of a compliant conductor-based inductive-capacitive circuit onto a commercial soft contact lens.
  • Testing sensor performance in animal models (rabbits, dogs) and pilot human studies (healthy and glaucomatous eyes).

Main Results:

  • The developed sensor demonstrates the highest IOP sensitivity reported for wearable soft contact lens sensors.
  • Stable and accurate IOP measurements were achieved under recumbent, closed-eye sleep conditions.
  • Preliminary data support ocular tolerability and feasible sensor performance for posture-dependent IOP tracking and detection of sleep-relevant pressure elevations.

Conclusions:

  • The novel soft contact lens sensor effectively addresses limitations of previous devices for nocturnal IOP monitoring.
  • This technology enables at-home monitoring of nocturnal IOP dynamics, advancing glaucoma management.
  • The sensor shows potential for tracking posture-dependent IOP changes and identifying sleep-related pressure elevations.