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Related Experiment Video

Updated: Jun 25, 2026

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Published on: August 10, 2019

Thermo-Responsive Living Microspheroids Enable a Regenerative Living Disk-Drive System for DNA Data Storage.

Hao Luo^1,2,3, JinKai Gao^1,2,3, XiangXiang Huang^1,2,3

¹Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)

|June 23, 2026

Summary

Scientists developed a regenerative Living Disk-Drive using engineered living memory microspheroids (ELMMs) for reusable DNA data storage. This system enables closed-loop retrieval, regeneration, and data rewriting, overcoming limitations of traditional DNA memory.

Keywords:

DNA data storage engineered living memory microspheroids in vivo DNA memory living disk–drive system regenerative storage

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Last Updated: Jun 25, 2026

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

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Published on: August 10, 2019

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Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

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Published on: October 25, 2018

Area of Science:

Biotechnology
Synthetic Biology
Data Storage

Background:

DNA offers high information density and stability but lacks reusable architecture and faces destructive readout.
Current DNA data storage methods are not easily addressable or regenerative at the device level.

Purpose of the Study:

To develop a regenerative, physically addressable architecture for DNA data storage.
To overcome limitations of destructive readout and enable reusable DNA memory systems.

Main Methods:

Engineered living memory microspheroids (ELMMs) encapsulating data-encoded bacteria were developed.
A Living Disk-Drive system was created using a lyophilized ELMM database, an Optical Retriever, and a desktop-scale Living Drive.
CRISPR-Cas12a/λ-Red system enabled rewriting of data sequences and retrieval tags within ELMMs.

Main Results:

The Living Disk-Drive system demonstrated closed-loop retrieval, regeneration, and database replenishment.
ELMMs retained data retrieval, bacterial regrowth, and sequence recovery after four months of storage and 13 lyophilization-rehydration cycles.
An extensible architecture for physically manageable and regenerative DNA memory was established.

Conclusions:

The Living Disk-Drive system provides a novel, regenerative approach to DNA data storage.
This architecture addresses key limitations of current DNA memory technologies, enabling practical, long-term data management.
The system offers a foundation for future advancements in biological data storage solutions.