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Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality

Harshavardhan Sanekommu1, Sowmya Dandu1, Sneha K Jayaswal2

  • 1Department of Medicine, Jersey Shore University Medical Center, Neptune City, New Jersey, USA.

European Journal of Gastroenterology & Hepatology
|June 23, 2026
PubMed

Insights

Patients with alcohol-associated hepatitis and atrial fibrillation face higher in-hospital mortality. Cirrhosis significantly worsens outcomes for these patients, highlighting the need for early intervention.

Area of Science:

  • Hepatology
  • Cardiology
  • Critical Care Medicine

Background:

  • Alcohol consumption is a known risk factor for atrial fibrillation.
  • Outcomes for patients with atrial fibrillation and acute alcohol-associated hepatitis are not well-documented.

Purpose of the Study:

  • To investigate the outcomes of patients with alcohol-associated hepatitis and concurrent atrial fibrillation.
  • To assess the impact of cirrhosis on mortality in this patient population.

Main Methods:

  • Retrospective analysis of the National Inpatient Sample (2016-2019).
  • Comparison of patients with and without atrial fibrillation, including subgroup analysis for cirrhosis.
  • Multivariate logistic and linear regression analysis using STATA 16.1.

Main Results:

  • 5.8% of 475,600 patients with alcohol-associated hepatitis had atrial fibrillation.
  • Atrial fibrillation was associated with nearly double in-hospital mortality (6.9% vs. 3.9%) and increased acute kidney injury risk.
  • Cirrhosis in patients with alcohol-associated hepatitis and atrial fibrillation led to a significantly higher mortality rate (11.3%).

Conclusions:

  • Patients with alcohol-associated hepatitis and atrial fibrillation have an elevated risk of in-hospital mortality.
  • The presence of underlying cirrhosis exacerbates this mortality risk.
  • Early identification of concomitant atrial fibrillation in alcohol-associated hepatitis patients may enable timely interventions.
Abstract

Keywords:
alcoholic hepatitisatrial fibrillationliver cirrhosis

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