Related Experiment Video
Updated: Jun 25, 2026
08:49
Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
Published on: October 6, 2023
Isolated Peripheral Nervous System Presentation in Ma/Ma2-Associated Autoimmunity
Andreu Vilaseca1,2, Macarena Villagrán-García3,4, Antonio Farina3,4
1Center for Multiple Sclerosis and Autoimmune Neurology, Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN.
Neurology(R) Neuroimmunology & Neuroinflammation
|June 23, 2026
Summary
Ma/Ma2 antibodies rarely cause isolated peripheral nervous system (PNS) autoimmunity. This study found PNS syndromes like sensory neuronopathy in 3% of patients, often linked to cancer.
Area of Science:
- Neurology
- Immunology
- Oncology
Background:
- Ma/Ma2-associated neurologic autoimmunity typically affects the central nervous system (CNS).
- Isolated peripheral nervous system (PNS) involvement is infrequently reported in Ma/Ma2 autoimmunity.
Purpose of the Study:
- To determine the frequency of isolated PNS presentations in patients with Ma/Ma2 antibodies.
- To describe the clinical syndromes associated with isolated PNS involvement in Ma/Ma2 autoimmunity.
Main Methods:
- A nested case series design was employed within multicenter cohorts.
- Patients with confirmed Ma/Ma2 antibodies (tissue-based assay and line-blot) and isolated PNS involvement were included.
Main Results:
- Seven out of 212 patients (3%) exhibited isolated PNS involvement.
- Reported PNS syndromes included sensory neuronopathy, myeloradiculopathy, radiculoplexopathy, motor neuronopathy, and multiple mononeuropathy.
- Cancer was identified in 86% of affected patients, with various types including mesothelioma, lung, and breast cancer.
Conclusions:
- Isolated PNS involvement is a rare but recognized manifestation of Ma/Ma2-associated autoimmunity.
- Consider Ma/Ma2 antibody testing for patients presenting with neuronopathies and unexplained non-length-dependent neuropathies.
More Related Videos
Related Concept Videos
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:22Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:20Myasthenia Gravis: Overview and Treatment
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...