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Updated: Jun 25, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
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Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

Published on: June 23, 2026

Rational design and structural insights of osthole-derived selective AKR1C3 inhibitors with cellular activity

Xuehua Zheng1, Ping Huang1, Jing Mi1

  • 1Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou 511436, China.

Bioorganic Chemistry
|June 23, 2026
PubMed
Abstract

Keywords:
AKR1C3Coumarin derivativesCrystallographic analysisProstate cancerSelective inhibitionStructure-based drug design

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