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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Jun 25, 2026

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
08:15

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

Published on: February 11, 2014

Combined bladder-kidney transplantation: first-in-human feasibility trial.

Nima Nassiri1, Inderbir S Gill2

  • 1UCLA Kidney and Bladder Transplant Programs, UCLA Department of Urology, University of California Los Angeles, Los Angeles, CA, USA.

Lancet (London, England)
|June 23, 2026
PubMed
Summary

This first-in-human bladder transplant shows a new surgical option is feasible for bladder dysfunction. The patient maintained good bladder and kidney function for over six months post-transplant.

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Last Updated: Jun 25, 2026

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Area of Science:

  • Urology
  • Transplantation Immunology
  • Regenerative Medicine

Background:

  • Current treatments for terminal bladder dysfunction, such as intestinal reconstruction, have significant risks, especially for immunosuppressed patients.
  • Vascularised composite bladder allograft transplantation is explored as a less morbid alternative.

Purpose of the Study:

  • To assess the safety and technical feasibility of combined kidney and bladder transplantation in a first-in-human trial.
  • To evaluate the immunological and functional outcomes of bladder allograft transplantation.

Main Methods:

  • An ongoing phase 0 feasibility trial involving adult patients (18-70 years) with non-functional bladders undergoing combined bladder-kidney transplantation.
  • Primary endpoints include surgical completion, graft perfusion, and patient safety via adverse event monitoring.

Main Results:

  • The first-in-human combined transplant was technically successful with good organ perfusion.
  • Post-transplant, the patient demonstrated sustained renal and bladder allograft function, including continence and spontaneous voiding, with no signs of rejection at 6 months.
  • A urine leak and wound breakdown occurred on postoperative day 25 but were surgically managed successfully.

Conclusions:

  • First-in-human combined bladder-kidney transplantation is technically feasible.
  • Bladder allograft transplantation shows promise as a viable option for select patients with terminal bladder dysfunction, particularly those already on immunosuppression.