Anti-inflammatory effect of Curcuma zedoaria ethanol extract on high-fat diet-induced obesity in mice

Curcuma zedoaria may serve as a promising material for preventing and/or improving lifestyle-related diseases, considering its known in vitro adiponectin-elevating effects. Here, we aimed to determine the effects of a C. zedoaria ethanol extract (CZE) on high-fat diet (HFD)-induced obesity in C57BL/6 N mice, to elucidate its effects on lifestyle-related diseases. CZE treatment with an HFD (HFD-CZE) reduced liver weight, subcutaneous fat, mesenteric fat, and hepatic lipid accumulation, along with alleviating the levels of plasma triglyceride, total-cholesterol, low density lipoprotein-cholesterol, aspartate aminotransferase, and alanine aminotransferase relative to those in the HFD group. Decreased messenger ribonucleic acid (mRNA) expressions of Tnfa and Il6 and increased mRNA expression of adiponectin were observed in epididymal white adipose tissue (eWAT) of the HFD-CZE group. CZE also reduced hepatic Tnfa and Fabp4 mRNA expressions. Thus, C. zedoaria may ameliorate obesity-induced whole-body inflammation, potentially aiding in preventing and improving obesity and subsequent lifestyle-related diseases.