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Related Experiment Videos

Clinical Practice Guideline for Spontaneous Isolated Superior Mesenteric Artery Dissection (2025 Edition).

Jin Ling1, Jinjian Sun1, Yuhang Hou1

  • 1Department of General and Vascular Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Annals of Vascular Surgery
|June 23, 2026
PubMed

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Summary

Spontaneous isolated superior mesenteric artery dissection (SISMAD) is rare but serious. Evidence-based guidelines are needed, but current recommendations for SISMAD management lack high-quality evidence, highlighting the need for more research.

Area of Science:

  • Vascular Surgery
  • Clinical Guidelines

Background:

  • Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a rare, life-threatening vascular condition.
  • Optimal medical management strategies for SISMAD are not well-established, necessitating evidence-based guidelines.

Purpose of the Study:

  • To develop evidence-based clinical practice guidelines for the management of SISMAD.
  • To synthesize current evidence on SISMAD presentation, imaging, classification, treatment, and follow-up.

Main Methods:

  • Adoption of the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology.
  • Utilization of the European Society of Cardiology (ESC) grading system for evidence quality (A, B, C).
  • Systematic literature review across eight key topics related to SISMAD.
Keywords:
Artery dissectionEndovascular treatmentMesenteric ischemiaRecommendationSuperior mesenteric artery

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Main Results:

  • Nineteen recommendations were formulated based on a review of available literature.
  • A significant portion of the recommendations were supported by low or moderate-quality evidence.
  • Only a minority of recommendations were based on high-quality evidence.

Conclusions:

  • Current evidence supporting SISMAD management recommendations is limited.
  • There is an urgent need for well-designed clinical studies and prospective research.
  • Further research is crucial to refine and improve the treatment strategies for SISMAD.