Laboratory Perspectives on Assay Selection and Implementation of PlGF-Based Testing for Suspected Preterm...

Blood-based biomarker testing for placental growth factor (PlGF) for preeclampsia is gaining adoption as diagnostic assays have become increasingly available in Canada. However, guidance on the diagnostic and prognostic thresholds for various PlGF-based tests is not standardized nor interchangeable. The implementation of PlGF-based testing in a clinical setting requires laboratory support to advise on the assay selection due to test configuration, handling, and report interpretation. To support dialogue among clinicians and laboratory stakeholders, this brief review covers the currently available assays in Canada and describes their main studies in preterm preeclampsia, single cutoffs versus gestational age ranges, and technical considerations.