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Updated: Jun 25, 2026

A Swine Model of Neonatal Asphyxia

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Rethinking Neonatal Surgical Urgency: Effective Delay with Internal Flow Restrictors.

Lindsey M Reynolds¹, Seth E M Wolf², Rebekah R Boyd³

¹Duke University School of Medicine, Durham, NC, USA; Duke Congenital Heart Surgery Research and Training Laboratory, Durham, NC, USA.

The Annals of Thoracic Surgery

|June 23, 2026

Summary

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This summary is machine-generated.

Percutaneous pulmonary flow restrictors effectively manage pulmonary overcirculation in high-risk neonates, bridging them to surgical decisions. This adjustable strategy improves physiologic stability and supports weight gain before definitive treatment.

Area of Science:

Pediatric Cardiology
Interventional Cardiology
Neonatology

Background:

Neonates with complex congenital heart disease often experience pulmonary overcirculation.
Early surgical intervention can be risky due to instability, prematurity, or comorbidities.

Purpose of the Study:

To evaluate the efficacy of percutaneous pulmonary flow restrictors as a bridge-to-decision strategy in high-risk neonates.
To assess the impact on hemodynamic parameters, physiologic stabilization, and subsequent management.

Main Methods:

Retrospective review of 38 neonates and infants undergoing percutaneous pulmonary flow restrictor placement.
Assessment of hemodynamic (pulmonary-to-systemic flow ratio) and laboratory (lactate, creatinine) parameters pre- and post-placement.
Evaluation of outcomes including stabilization, weight gain, interventions, and complications.

Related Experiment Videos

Last Updated: Jun 25, 2026

A Swine Model of Neonatal Asphyxia

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Main Results:

Flow restrictor placement significantly reduced pulmonary blood flow (median P/S ratio from 3.6 to 0.84).
Rapid improvements in lactate and creatinine were observed.
82% proceeded to surgery, with a median weight gain of 370g; 13% required repeat intervention.

Conclusions:

Percutaneous pulmonary flow restrictors are a feasible and adaptable strategy for temporizing pulmonary overcirculation in high-risk neonates.
This approach supports physiologic optimization and allows for individualized flow modulation.
It facilitates assessment of clinical trajectory and candidacy for definitive intervention.