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Updated: Jun 25, 2026

Rapid Isolation of Human Breast Milk-Derived Extracellular Vesicles
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Published on: November 14, 2025

Breast milk exosomes: Implications for Brain function and Oncogenesis.

Elisavet Kosma1, Dimitrios Vrachas1, Panagiotis Rodoglou2

  • 1Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.

Neuroscience and Biobehavioral Reviews
|June 23, 2026
PubMed
Summary

Breast milk derived exosomes (MDEs) show promise for infant neurodevelopment and brain health. These nanoparticles can also serve as drug delivery vehicles for brain tumors, activating cell death pathways and boosting anti-tumor immunity.

Keywords:
BBBBreast milk exosomesDrug deliveryExtracellular vesiclesImmune modulationMiRNAsNeurodevelopmentTumor microenvironment

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Area of Science:

  • Exosomes and extracellular vesicle research
  • Neuroscience and neurobiology
  • Cancer biology and therapeutics

Background:

  • Breast milk derived exosomes (MDEs) are crucial for fetal-maternal communication and infant development.
  • MDE composition is influenced by maternal factors, impacting infant immunity, gut health, and brain development.
  • MDEs can cross the blood-brain barrier, offering therapeutic potential for neurological conditions.

Purpose of the Study:

  • To review the latest research on MDEs' role in brain health.
  • To explore MDEs as potential drug delivery systems for brain tumors.
  • To highlight MDEs' therapeutic capabilities in preclinical cancer models.

Main Methods:

  • Review of current scientific literature on MDEs.
  • Analysis of preclinical studies involving MDEs in brain health and cancer models.
  • Evaluation of MDEs' mechanisms of action, including cargo delivery and immune modulation.

Main Results:

  • MDEs contribute to neurodevelopment, neuroinflammation regulation, and stem cell differentiation.
  • MDEs demonstrate efficacy in preclinical brain tumor models.
  • MDEs activate apoptotic pathways and promote anti-tumor immune responses within the tumor microenvironment.

Conclusions:

  • MDEs possess significant therapeutic potential for brain health and neurological disorders.
  • MDEs show promise as targeted drug delivery vehicles for brain tumors.
  • Further research into MDEs could lead to novel cancer therapies and neuroprotective strategies.