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Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

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Updated: Jun 25, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Associations Between Routine Vaccinations and the Risk of New-Onset Idiopathic Uveitis.

Matthew J Schulgit1, Suraj Bala2, Victor Bellanda2

  • 1Cleveland Clinic Cole Eye Institute, Cleveland, OH; Uveitis Center of Excellence, Cleveland Clinic Cole Eye Institute, Cleveland, OH; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.

American Journal of Ophthalmology
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Vaccinations for COVID-19, HPV, and zoster were linked to a significantly lower risk of new-onset idiopathic uveitis (NIU). This study highlights the protective effect of these vaccines against NIU development.

Keywords:
COVID-19human papilloma virusuveitisvaccinationvaricella zoster virus

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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

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Last Updated: Jun 25, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Area of Science:

  • Immunology
  • Ophthalmology
  • Vaccinology

Background:

  • Idiopathic uveitis (NIU) is an inflammatory eye condition with complex etiology.
  • Understanding potential modifiable risk factors for NIU is crucial for prevention and management.

Purpose of the Study:

  • To investigate the association between specific vaccinations and the subsequent risk of developing new-onset idiopathic uveitis (NIU).

Main Methods:

  • A retrospective cohort study utilized electronic health records from US health systems.
  • Propensity-score matched controls were used to compare individuals who received COVID-19, HPV, varicella, or zoster vaccines with unvaccinated individuals.
  • Incidence of NIU at 3, 6, and 12 months post-vaccination was the primary outcome, with risk ratios calculated.

Main Results:

  • All tested vaccinations demonstrated a reduced risk of NIU within 12 months compared to controls.
  • Significant risk reductions were observed for COVID-19 (65%), HPV (56%), varicella (71%), live zoster (68%), and recombinant zoster (69%) vaccines.
  • These protective associations remained consistent even when excluding individuals with prior viral infection diagnoses.

Conclusions:

  • Vaccination against COVID-19, HPV, varicella, and zoster is associated with a decreased risk of idiopathic uveitis.
  • Findings suggest a role for immune modulation through vaccination in mitigating the risk of NIU.
  • This research underscores the potential benefits of vaccination beyond infectious disease prevention.