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The malignancy within: what cancer teaches us about human bonds
Bruno B Andrade1, Mariana Araújo-Pereira2
1Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States; Laboratory of Clinical and Translational Research, Gonçalo Moniz Institute, Oswaldo Cruz, Foundation, Salvador, Brazil; The Bright Lab, MONSTER Institute for Education, Care, Research, and Technological Development in Health, Salvador, Brazil.
Cancer, a disease originating within the body, offers metaphors for social dysfunction. Understanding cancer biology provides insights into healing relationships and communities by addressing internal, harmful dynamics.
Area of Science:
- Integrative biology and social science.
- Biomedical and ethical analysis of malignancy.
Background:
- Cancer arises from internal cellular dysfunction, deviating from cooperative biological roles.
- Malignancies present metaphors for interpersonal and social pathologies, including boundary violations and exploitation.
Purpose of the Study:
- To explore cancer as a metaphor for social and relational dysfunction.
- To draw parallels between cancer biology (hallmarks, tumor microenvironment, immunotherapy) and social pathologies.
- To derive lessons in resilience, intervention, and repair from cancer biology for societal health.
Main Methods:
- Conceptual analysis integrating cancer biology principles with social science theories.
- Application of 'hallmarks of cancer' and tumor microenvironment concepts to relational dynamics.
- Examination of immunotherapy and remission biology for insights into social repair and resilience.
Main Results:
- Cancer biology mirrors relational pathologies: boundary violations, resource exploitation, harm masking, and spread of dysfunction.
- Tumor evasion strategies parallel social manipulation of tolerance and complicity.
- Cancer therapies and remission highlight the need for precise intervention and the possibility of repair without erasure.
Conclusions:
- Reflecting on malignancy as metaphor reveals that healthy relationships require balance: growth vs. restraint, vigilance vs. tolerance, repair vs. prevention.
- Cancer serves as a teacher, offering insights into recognizing, containing, and healing internal malignant dynamics in individuals and communities.
- The study underscores the interconnectedness of biomedical understanding and social/ethical well-being.
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