HLA selected red cell transfusions to prevent HLA sensitisation: a prospective, double-blinded, randomised controlled...

Area of Science:

• Immunology
• Transfusion Medicine
• Transplantation

Background:

• Human Leucocyte Antigen (HLA) sensitization from red cell transfusions complicates transplantation.
• Preventing HLA sensitization is crucial for improving transplant outcomes.

Purpose of the Study:

• To evaluate the efficacy of HLA-selected red cell transfusions in preventing blood donor-specific HLA antibodies (bDSA).

Main Methods:

• Prospective, randomized controlled, double-blinded study.
• Adults and pediatric cardiac surgery patients received either HLA-selected or unselected red cells.
• Primary outcome: cumulative incidence of de novo bDSA.

Main Results:

• No de novo bDSA detected in participants receiving only trial products.
• De novo bDSA detected in participants receiving unselected red cells.
• Intention-to-treat analyses showed no significant difference due to high rates of non-trial product use.

Conclusions:

• HLA-selected red cell transfusions show potential in preventing HLA sensitization.
• Larger studies are needed to confirm the efficacy of blood donor selection for avoiding HLA sensitization.