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Updated: Jun 25, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

T1W/T2W Ratio to Assess Brain Microstructural Damage in Multiple Sclerosis: A Multicenter Study.

Loredana Storelli1, Paolo Preziosa1, Nicolò Tedone1

  • 1From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania "Luigi Vanvitelli", Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.

AJNR. American Journal of Neuroradiology
|June 23, 2026
PubMed
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Profiling the long-term risk of severe adverse events in a cohort of multiple sclerosis patients treated with different treatment sequences: Results from the Italian Multiple Sclerosis and Related Disorders Registry (I-MS&RD) (ProSA study).

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This summary is machine-generated.

The T1-weighted/T2-weighted ratio reveals compartment-specific brain changes in multiple sclerosis (MS) patients, correlating with disease progression, disability, and cognitive function across various MS phenotypes.

Area of Science:

  • Neuroimaging
  • Biomarkers
  • Multiple Sclerosis Research

Background:

  • The T1-weighted/T2-weighted ratio is a proposed MRI biomarker for myelin integrity in multiple sclerosis (MS).
  • Its specificity and compartment-specific alterations across MS phenotypes remain debated.
  • Investigating these ratios can offer insights into MS pathophysiology.

Purpose of the Study:

  • To investigate compartment-specific T1-weighted/T2-weighted ratio alterations in MS.
  • To examine differences across MS phenotypes and age at onset.
  • To correlate these ratios with clinical disability and cognitive performance.

Main Methods:

  • A multicenter study involving 918 MS patients and 272 healthy controls.
  • Standardized 3D T1- and T2-weighted MRI scans were acquired.

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  • T1-weighted/T2-weighted ratios were computed, and associations with clinical/cognitive data were analyzed.

    • Main Results:

    • MS patients showed altered T1-weighted/T2-weighted ratios in lesions, white matter, grey matter, thalamus, and deep grey matter compared to controls.
    • Differences varied significantly across MS phenotypes (SPMS, RRMS, CIS, PPMS) and age at onset.
    • Altered ratios correlated with disease duration, disability, and cognitive function.

    Conclusions:

    • T1-weighted/T2-weighted MRI mapping provides compartment-specific insights into tissue integrity in MS.
    • These ratios offer complementary information on clinical outcomes across the MS spectrum.
    • This technique aids in understanding MS pathophysiology and progression.