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Updated: Jun 25, 2026

Spectroscopic Super-resolution Imaging of DNA Molecules using Intrinsic Contrast

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Published on: March 6, 2026

Enhancing Spectral Resolution for Detecting Chirality-Induced Spin Selectivity in DNA Hairpins Using Photogenerated

Elisabeth I Latawiec¹, Graeme Copley¹, Yunfan Qiu¹

¹Department of Chemistry, Institute for Quantum Information Research and Engineering, and Center for Molecular Quantum Transduction, Northwestern University, Evanston, Illinois 60208-3113, United States.

The Journal of Physical Chemistry Letters

|June 23, 2026

Summary

Chirality-induced spin selectivity (CISS) uses molecular chirality to control electron spin states. DNA

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Published on: February 10, 2022

Area of Science:

Molecular chirality and spin electronics
DNA nanotechnology
Quantum information science

Background:

Chirality-induced spin selectivity (CISS) enables control of electron spin states.
Chiral molecules and materials can induce spin polarization during electron or hole transmission.
DNA's inherent chirality offers a unique platform for spintronic applications.

Purpose of the Study:

Investigate the contribution of CISS to spin-correlated radical pair (SCRP) formation in donor-chiral bridge-acceptor (D-Bχ-A) molecules.
Quantify the CISS effect in DNA-based molecular systems.
Explore the potential of DNA chirality for quantum information technologies.

Main Methods:

Synthesized D-Bχ-A molecules with naphthalene-1,8:4,5-bis(dicarboximide) (NDI) as donor and perylene-d11 (Per-d11) as acceptor, linked by a B-form DNA helix.
Utilized photoexcitation of NDI to initiate hole transfer through the DNA.
Employed time-resolved electron paramagnetic resonance (TR-EPR) spectroscopy at X- and Q-bands to analyze SCRP formation and CISS contribution.

Main Results:

Photoexcitation led to hole transfer and formation of NDI•−-Per-d11•+ SCRPs.
TR-EPR spectral simulations necessitated a 34-62% CISS contribution to the initial SCRP state.
The narrow linewidth of Per-d11•+ and g-factor differences facilitated accurate CISS evaluation.

Conclusions:

Demonstrated significant CISS contribution in DNA-based molecular systems.
Validated the use of DNA as a chiral scaffold for spin manipulation.
Highlighted the potential of harnessing DNA chirality for advancing quantum information technologies.